CORRELATION BETWEEN METABOLIC SYNDROME AND SUBCLINICAL HYPOTHYROIDISM IN PATIENTS PRESENTING TO OPDS AT PAF HOSPITAL ISLAMABAD

Abstract

Abstract

Background: Subclinical hypothyroidism (SCH), marked by elevated levels of thyroid-stimulating hormone (TSH) has a strong bearing upon on metabolic processes and exploring a correlation of SCH and metabolic syndrome (MetS) would be useful in management of metabolic related disorders especially among the cardiac patients.

Objective: To determine the correlation between metabolic syndrome and subclinical hypothyroidism in patients presenting to OPDs of PAF Hospital Islamabad.

Material and Methods: This case control study was conducted at the Department of Medicine, PAF Hospital Islamabad, Pakistan from 1st of March 2023 to 31st of August 2023. Total number of 278 patients with metabolic syndrome were enrolled in study group while another 278healthy individuals not having features of MetS were enrolled in control group.  Demographics, clinical history was recorded and biochemical analysis including Fasting Blood sugar, Total Cholesterol, Triglycerides and serum TSH and FT4 was done for each individual. The primary outcome was to find the correlation as assessed by the prevalence of subclinical hypothyroidism in patients having metabolic syndrome.

Results:The Mean±SD of age in this study was 49.05±11.18 years with a higher number of male gender compared to female (61.33% Vs 38.64%). The results of the study showed significantly higher number of patients with SCHin the study group compared to the control group (18.34 % Vs 7.19 %, p=0.00).

Conclusion:It is concluded that subclinical hypothyroidism is significantly correlated with metabolic syndrome.